GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9847710 | 1 | rs4687697 | chr3:53090490 | GLYCTK | chr3:52321836-52329271:+ | -0.17 | -3.79 | 0.000167 | Ulcerative colitis |
| THCA | cis | rs9847710 | 1 | rs4687697 | chr3:53090490 | NT5DC2 | chr3:52558386-52569093:- | -0.15 | -3.4 | 0.000737 | Ulcerative colitis |
| THCA | cis | rs2564921 | 1 | rs4687701 | chr3:53121276 | ITIH4 | chr3:52847007-52866554:- | -0.16 | -4.48 | 9.23E-6 | Height |
| THCA | cis | rs2564921 | 1 | rs4687701 | chr3:53121276 | RFT1 | chr3:53122503-53164470:- | 0.74 | 17.76 | 1.43E-54 | Height |
| THCA | cis | rs1031925 | 1 | rs4687721 | chr3:51598254 | HEMK1 | chr3:50606583-50622419:+ | 0.17 | 3.73 | 0.000216 | Melanoma |
| THCA | cis | rs1031925 | 1 | rs4687721 | chr3:51598254 | TEX264 | chr3:51705222-51738338:+ | -0.18 | -5.17 | 3.5E-7 | Melanoma |
| THCA | cis | rs8135828 | 1 | rs468795 | chr22:29955450 | NIPSNAP1 | chr22:29950800-29977144:- | -0.34 | -5.11 | 4.7E-7 | Lipid traits |
| THCA | cis | rs8135828 | 1 | rs468852 | chr22:29956156 | NIPSNAP1 | chr22:29950800-29977144:- | -0.32 | -4.74 | 2.83E-6 | Lipid traits |
| THCA | cis | rs4234798 | 1 | rs4689088 | chr4:7222253 | SORCS2 | chr4:7194374-7744563:+ | -0.35 | -8.95 | 8.17E-18 | Insulin-like growth factors |
| THCA | cis | rs4234798 | 1 | rs4689653 | chr4:7223319 | SORCS2 | chr4:7194374-7744563:+ | -0.34 | -8.73 | 4.4E-17 | Insulin-like growth factors |
| THCA | cis | rs55962025 | 1 | rs4690071 | chr4:3086753 | C4orf44 | chr4:3250767-3265839:+ | -0.32 | -6.56 | 1.43E-10 | Parental longevity (mother's age at death) |
| THCA | cis | rs55962025 | 1 | rs4690071 | chr4:3086753 | GRK4 | chr4:2965343-3042474:+ | -0.23 | -3.87 | 0.000126 | Parental longevity (mother's age at death) |
| THCA | cis | rs8396 | 1 | rs4690909 | chr4:159629151 | ETFDH | chr4:159593277-159629839:+ | -0.18 | -4.48 | 9.36E-6 | Blood metabolite levels;Metabolite levels;Metabolic traits;Acylcarnitine levels |
| THCA | cis | rs8396 | 1 | rs4690909 | chr4:159629151 | PPID | chr4:159630280-159644552:- | 0.2 | 3.81 | 0.000158 | Blood metabolite levels;Metabolite levels;Metabolic traits;Acylcarnitine levels |
| THCA | cis | rs4691139 | 1 | rs4691139 | chr4:165908721 | C4orf39 | chr4:165878100-165880273:+ | 0.19 | 5.25 | 2.29E-7 | Ovarian cancer in BRCA1 mutation carriers |